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KMID : 1007320070130010014
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Journal of the Korean Society of Menopause
2007 Volume.13 No. 1 p.14 ~ p.20
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Effect of Lipid Profile and Inflammatory Marker on Serum γ-GT in Pre- and Post-menopausal Women
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Choi Hee-Jeong
Yoon Joo-Ho
Kim Sang-Hwan
Yoon Kyung-Sun
Hong Seung-Hee
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Abstract
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Objectives: The purpose of this study is to find out whether the lipid profile and inflammatory marker affect serum Gammaglutamyl transferase (γ-GT) in pre- and post-menopausal women.
Methods: Among the women who have visited the Health Promotion Centre in a university hospital between April, 2004 and April, 2005, we selected 1,774 women ruling out viral hepatitis carriers.
Results: While serum γ-GT was significantly correlated to all the serum lipid profile in pre-menopausal women, it didn’t have correlation with CRP. On the other hand, in post-menopausal women, total cholesterol, triglyceride, low density lipoprotein (LDL), and CRP were significantly correlated to serum γ-GT. In multiple regression analysis adjusting for potential confounders, the total cholesterol, triglyceride, and high density lipoprotein (HDL) were the variables which affect serum γ-GT in pre-menopausal women and total cholesterol and CRP were the variables in post-menopausal women.
Conclusion: In this study, total cholesterol, HDL, and TG have influence on serum γ-GT in pre-menopausal women and total cholesterol and CRP affect serum γ-GT in post-menopausal women.
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KEYWORD
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Gammaglutamyl transferase, Menopause, Lipid, C-reactive protein
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